Strengthening the Immune System Naturally

The immune system comprises a network of cells, processes, and chemicals that constantly work to combat invaders, including external pathogens such as viruses, toxins, and bacteria[1].

A lack of vital vitamins and minerals like zinc, Vitamin D, and Vitamin C can weaken the immune system. By supplementing these deficiencies with nutritional supplements, one can significantly boost the immune response and enhance the body’s natural defense mechanisms.

Below is a compilation of dietary supplements, including vitamins and minerals, that are known to fortify the immune system and assist in effectively combating infections and potential illnesses.

The immune system retains a memory of every microorganism it has successfully combated.

Fact 1 of 4

Immune System Disorders and Cancer Risk in the Netherlands

A study[2] analyzing data from the Dutch national registry of primary immune deficiency (PID) patients, following the European Society for Immunodeficiencies (ESID) definitions, found an overall prevalence of PID at 4.0 per 100,000 inhabitants.

The study revealed that almost 10% of PID patients suffered from malignancy, particularly lymphoma and skin cancer, indicating a more than 2.3-fold increased relative risk of developing any malignancy compared to the general Dutch population. This study emphasizes the significant health implications of PIDs, including an increased risk of cancer​​.

Vitamin D

Vitamin D, a group of five fat-soluble compounds, plays a crucial role in the body’s use of calcium and phosphorus. Some forms of Vitamin D are produced in the body, while others need to be ingested through food.

This vitamin enhances the ability of white cells to fight certain pathogens and also helps reduce inflammation[3].

Research indicates that Vitamin D supplementation can bolster protection against respiratory infections. A systematic review and meta-analysis from 2012 demonstrated[4] that those who received Vitamin D had significantly fewer infections compared to a control group, in both children and adults.

Numerous studies have investigated the effect of Vitamin D on COVID-19 patients. A 2022 systematic review[5], encompassing 28 studies, found a correlation between Vitamin D levels and the incidence, severity, and mortality rate of COVID-19.

While Vitamin D doesn’t eradicate the virus, its deficiency may heighten the risk of contracting COVID-19 and exacerbate the severity and progression of the disease, including mortality.

Vitamin C

Vitamin C, a water-soluble essential vitamin necessary for collagen production, is not naturally produced in humans, monkeys, and a few other animals.

Various studies have explored Vitamin C’s role in preventing cancer, cardiovascular diseases, chronic conditions, and colds. Its concentration in immune cells decreases during an infection, highlighting its importance in the immune response.

Known as a potent antioxidant linked to immune function, Vitamin C has been proven beneficial in treating upper respiratory infections.

Inflammation serves as the body’s immune reaction to harmful germs.

Fact 2 of 4

A 1975 study[6] tested the efficacy of Vitamin C in treating winter ailments and colds. The study, involving 622 participants who received varying doses of Vitamin C, showed that those taking Vitamin C experienced milder symptoms compared to those in the placebo group.

Zinc

Zinc, a trace mineral, is vital for numerous enzymes and other biological functions in the body. It plays a role in immune cell communication, reducing inflammation, and blocking the entry of foreign bodies.

Zinc is known to inhibit the replication of rhinovirus and can lessen the duration and severity of colds[7] . A deficiency in zinc can impair immune function and increase susceptibility to various infections and diseases.

Long-term zinc consumption is deemed safe for adults in good health when taken[8] in daily doses below 40 mg. However, excessive intake may disrupt copper absorption and increase infection risk.

Curcumin

Curcumin, a polyphenol extracted from turmeric root, possesses strong anti-inflammatory properties and appears to enhance the immune response in animal studies.

Adding peperin (from black pepper) to curcumin supplements has been shown to increase intestinal absorption.

Developing a fever is an indication of the immune system’s active engagement.

Fact 3 of 4

A 2014 randomized study[9] investigated curcumin’s effects on cytokines in obese individuals. The findings suggested that curcumin could modulate the immune system.

Licorice

Licorice root contains numerous beneficial components, such as B vitamins, magnesium, zinc, iron, and glycyrrhizin, which can protect against viral infections.

A 2017 study[10] on the immunomodulatory activity of licorice polysaccharides in mice with CT 26 tumors showed significant tumor suppression and increased immune organ index.

Black Elderberry

Widely used in folk medicine, black elderberry has been studied for its effects on the immune system. Its fruits contain polyphenols, triterpenes, tannins, and other beneficial compounds[11].

Research highlights the role of phytochemicals in preventing and complementing the treatment of infections and inflammatory conditions[12].

Black elderberry is utilized as an antiviral and anti-allergy agent, particularly in treating flu and colds. A 2020 article[13] listed it among seven recommendations to reduce COVID-19 mortality.

Huang-Ki (Astragalus)

Huang-qi, or astragalus, a plant from the butterfly family, is widely used in traditional Chinese medicine for its immune-strengthening properties.

With aging, the effectiveness of the immune system tends to diminish.

Fact 4 of 4

A 2022 review examined astragalus polysaccharide’s immunomodulatory effects on immune organs[14]. The studies showed that it enhances the activity of various immune cells and stimulates cytokine and chemokine expression.

Its immunomodulatory properties make it a potential treatment for diseases like cancer, infection, diabetes, asthma, and autoimmune disorders, with notable anti-cancer effects.

Additional Supplements

Other supplements that have shown positive effects on the immune system in scientific studies include selenium, garlic, andrographis paniculata, echinacea, and propolis (bee glue).

Bibliography