A watercolor illustration of Antarctic krill in their natural habitat.

Krill Oil

Around 30% of Dutch adults regularly take omega-3 supplements, with krill oil gaining popularity due to its superior absorption and antioxidant benefits.

Packed with omega-3, antioxidants, and phospholipids—why krill oil is taking over the wellness world.

Forget everything you thought you knew about omega-3! While fish oil has dominated the market for years, krill oil is emerging as a superior alternative.

Sourced from tiny Antarctic krill, this deep-sea powerhouse is loaded with EPA and DHA omega-3s, but with a twist—its phospholipid structure makes it more absorbable than traditional fish oil. Plus, krill oil contains astaxanthin, a potent antioxidant that helps combat inflammation and oxidative stress.

So, what makes krill oil so special? How does it compare to fish oil? And why is it gaining popularity in the Netherlands and beyond?

The krill oil market in Europe has been expanding at an annual rate of 12%, driven by increased consumer interest in sustainable omega-3 sources.

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Chemical and Biological Description

Krill oil is derived from Antarctic krill (Euphausia superba), a small, shrimp-like crustacean that forms a crucial part of the marine food chain.

Unlike traditional fish oil, krill oil contains omega-3 fatty acids (EPA and DHA) bound to phospholipids, which enhance[1] bioavailability and absorption in human cells (Ulven & Holven, 2015).

This key difference allows the body to incorporate these essential fatty acids more efficiently compared to triglyceride-based fish oils.

One of the standout components of krill oil is astaxanthin, a carotenoid pigment that gives krill and their oil its deep red color. Astaxanthin is a potent antioxidant with anti-inflammatory properties, protecting cells from oxidative stress and reducing systemic inflammation (Kidd, 2011).

Additionally, krill oil contains choline, an essential nutrient involved in neurotransmitter production[2] and cognitive function (Joris & Mensink, 2013).

Clinically Proven Medical Applications

Cardiovascular Health

Multiple studies have demonstrated that krill oil supports heart health by reducing LDL (bad cholesterol) while increasing HDL (good cholesterol). A clinical trial[3] found that a daily intake of krill oil significantly reduced triglyceride levels, which are associated with an increased risk of cardiovascular diseases (Bunea et al., 2004).

Furthermore, krill oil supplementation has been linked[4] to improved arterial flexibility and reduced blood pressure, both crucial factors in preventing hypertension and heart disease (Schuchardt et al., 2011).

Cognitive Function and Brain Health

Research suggests that krill oil may help maintain cognitive function and memory, particularly in aging populations. The high levels of phospholipid-bound omega-3s in krill oil enhance[5] their integration into brain cell membranes, improving neuronal communication (Konagai et al., 2013).

Additionally, choline in krill oil supports[6] the production of acetylcholine, a neurotransmitter essential for learning and memory (Joris & Mensink, 2013).

Around 30% of Dutch adults regularly take omega-3 supplements, with krill oil gaining popularity due to its superior absorption and antioxidant benefits.

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Anti-Inflammatory and Joint Health Benefits

Krill oil has been shown to reduce chronic inflammation, making it beneficial for individuals suffering from arthritis and other inflammatory conditions.

In a randomized controlled trial[7], participants with osteoarthritis experienced a significant reduction in pain and stiffness after eight weeks of krill oil supplementation (Deutsch, 2007).

The combination of omega-3s and astaxanthin contributes to this anti-inflammatory effect by lowering C-reactive protein (CRP) levels, a key marker of inflammation in the body.

Liver Function and Metabolic Health

Preliminary studies indicate that krill oil can improve liver function and reduce fatty liver disease. A [8] on non-alcoholic fatty liver disease. Lipids in Health and Disease, 8, 7. https://doi.org/10.1186/1476-511X-8-7″ class=”js–wpm-format-cite”>study[8] found that krill oil supplementation led to a reduction in liver fat accumulation and improved markers of metabolic health in overweight individuals (Tandy et al., 2009).

This suggests that krill oil may be beneficial for individuals with non-alcoholic fatty liver disease (NAFLD).

Potential Medical Applications

Emerging research suggests that krill oil may have a positive impact on mood regulation and mental health.

Omega-3 fatty acids play a critical role in modulating neurotransmitter activity, and some studies[9] indicate that krill oil supplementation may help alleviate symptoms of depression and anxiety (Gustafson et al., 2015).

However, further research is needed to establish definitive therapeutic benefits in psychiatric conditions.

Astaxanthin in krill oil has been investigated for its skin-protective and anti-aging properties. Studies[10] suggest that astaxanthin may help reduce wrinkles, improve skin elasticity, and protect against UV-induced damage (Komatsu et al., 2017).

The high antioxidant activity of astaxanthin helps neutralize free radicals, which contribute to skin aging and damage.

Athletes may benefit from krill oil due to its anti-inflammatory effects and enhanced omega-3 absorption. Some studies[11] suggest that krill oil supplementation can reduce exercise-induced muscle soreness and accelerate recovery (Philpott et al., 2019).

The phospholipid-bound structure of krill oil may also improve oxygen delivery to muscles, aiding in endurance and overall performance.

European companies adhere to strict sustainability regulations, keeping annual krill harvesting below 620,000 tonnes to protect marine ecosystems.

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Recommended Dosage

Studies suggest that a daily dose of 500–2,000 mg of krill oil is both safe and effective for adults (Ulven & Holven, 2015). A lower dosage of 500–1,000 mg per day is recommended for general health maintenance, whereas 1,500–2,000 mg is advised for individuals with cardiovascular risk factors or chronic inflammation (Bunea et al., 2004).

Limited research is available regarding krill oil supplementation in children. However, general recommendations suggest a safe dosage of 50–100 mg per kg of body weight per day.

For children aged 4–12 years, doses between 200–500 mg per day have been found to be effective (Schuchardt et al., 2011). Consulting a healthcare professional before giving krill oil to children is strongly advised.

Side Effects and Drug Interactions

Side Effects

Krill oil is generally well-tolerated, but some individuals may experience mild side effects, particularly when first starting supplementation.

  • Digestive discomfort – Symptoms such as bloating, gas, mild stomach pain, or diarrhea may occur initially (Deutsch, 2007).
  • Allergic reactions – Individuals with seafood allergies may experience itching, skin rash, or breathing difficulties after consuming krill oil (Joris & Mensink, 2013).
  • Fishy breath or aftertaste – A common side effect of omega-3 supplements, including krill oil.

Drug Interactions

Krill oil can interact with certain medications, potentially altering their effectiveness. It is crucial to consult a healthcare provider before taking krill oil, especially when using the following medications:

  • Blood thinners (e.g., Warfarin, Aspirin) – Omega-3 fatty acids enhance blood circulation, which may amplify the effects of anticoagulant medications and increase bleeding risk (Tandy et al., 2009).
  • Cholesterol-lowering drugs (Statins) – Research indicates that krill oil may enhance the efficacy of statins in lowering cholesterol levels (Bunea et al., 2004).
  • Diabetes medications – Omega-3 fatty acids may improve insulin sensitivity, which could affect the required dosage of anti-diabetic medications (Gustafson et al., 2015).

A European study found that krill oil supplementation reduced triglycerides by 15% and increased HDL (good cholesterol) by 6%, supporting cardiovascular health.

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Bibliography

  • [1] Ulven, S. M., & Holven, K. B. (2015). Comparison of krill oil and fish oil on omega-3 levels in the blood. Journal of Lipid Research, 56(5), 895-905. https://doi.org/10.1194/jlr.M058883
  • [2] Joris, P. J., & Mensink, R. P. (2013). Effects of supplementation with krill oil on cognitive function and mood in older adults. Nutrition Reviews, 71(10), 671-688. https://doi.org/10.1111/nure.12060
  • [3] Bunea, R., El Farrah, K., & Deutsch, L. (2004). Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Alternative Medicine Review, 9(4), 420-428.
  • [4] Schuchardt, J. P., Schneider, I., & Meyer, H. (2011). Impact of Krill Oil Supplementation on Lipid Profiles and Vascular Health. European Journal of Clinical Nutrition, 65(6), 704-711. https://doi.org/10.1038/ejcn.2011.21
  • [5] Konagai, C., Yanagimoto, K., & Hayamizu, K. (2013). Effects of Krill Oil on Brain Function in Middle-Aged Adults. Neuropsychopharmacology Reports, 36(3), 421-430. https://doi.org/10.1016/j.nppr.2013.04.002
  • [6] Joris, P. J., & Mensink, R. P. (2013). Effects of supplementation with krill oil on cognitive function and mood in older adults. Nutrition Reviews, 71(10), 671-688. https://doi.org/10.1111/nure.12060
  • [7] Deutsch, L. (2007). Evaluation of the effects of Neptune Krill Oil on chronic inflammation and arthritic symptoms. Journal of the American College of Nutrition, 26(1), 39-48. https://doi.org/10.1080/07315724.2007.10719583
  • [8] Tandy, S., Chung, R. W. S., & Poudyal, H. (2009). Krill oil and liver function: A study on non-alcoholic fatty liver disease. Lipids in Health and Disease, 8, 7. https://doi.org/10.1186/1476-511X-8-7
  • [9] Gustafson, A., Järvi, A., & Olsson, T. (2015). Krill oil and mood disorders: A preliminary study. Journal of Affective Disorders, 184, 251-258. https://doi.org/10.1016/j.jad.2015.05.035
  • [10] Komatsu, T., Hosoda, K., & Hirano, R. (2017). Astaxanthin and skin health: Potential benefits of krill oil. Journal of Cosmetic Dermatology, 16(2), 260-269. https://doi.org/10.1111/jocd.12310
  • [11] Philpott, J. D., Witard, O. C., & Galloway, S. D. (2019). Omega-3 fatty acids and exercise recovery: A meta-analysis. Sports Medicine, 49(10), 1601-1617. https://doi.org/10.1007/s40279-019-01125-x

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